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The Daily Insight

Does topical spironolactone work for acne?

Author

Sarah Garza

Updated on April 29, 2026

Previous studies revealed that topical spironolactone affects follicular duct cornification and comedones formation and decreases sebum production, so it can be one of the effective and safe treatments of acne [1].

Besides, how long before Spironolactone works for acne?

"If the oil glands do not make as much oil, there will be fewer blockages in the pores, less food to feed acne-causing bacteria, and less shininess," he says. Spironolactone results typically appear within a few weeks, but Zeichner says the drug reaches "peak effect" at around three months.

Additionally, why is spironolactone prescribed for acne? Spironolactone is a medication that contains anti-androgen activity - Androgens are male sex hormones, like testosterone. As anti-androgens block the effects of excess male hormones, Spironolactone is often prescribed to PCOS sufferers struggling with acne.

People also ask, does spironolactone help with acne?

Spironolactone (Aldactone) is a diuretic (a “water pill”), which means it is a drug that removes fluid from your body. It can be used to treat acne in women by targeting the hormonal causes of acne. Spironolactone is used to treat other conditions as well, including: Heart failure.

Does acne return after spironolactone?

Your acne can come back after taking spironolactone Spironolactone is not a cure-all pill and won't rid you of acne forever. It is prescribed to be taken daily but according to Dr Mahto, acne can return when it is discontinued. "Spironolactone can be safely taken for many years if necessary," she adds.

Related Question Answers

Is 50 mg of spironolactone enough for acne?

Spironolactone will help with acne on the face, back, and chest. The majority of sides effects associated with spironolactone are dose dependent; low-dose therapy (25–50 mg daily) generally is well tolerated, and even 100 mg daily is not problematic in most cases.

Is 25 mg of spironolactone enough for acne?

"In [high blood-pressure] cases, you typically take 200 mg a day as a recommended dose, but spironolactone tends to work well [for treating acne] at very low doses, as low as 25 mg." Another major plus about the drug: It's cheap!

Can spironolactone make you gain weight?

There are concerns that spironolactone can cause weight gain, but there isn't much evidence it does. For example, the package insert for the drug doesn't list weight gain as a side effect. Along with weight gain, many people worry that spironolactone will make their skin look worse when they first start taking it.

Does acne get worse before better on spironolactone?

"Most women should expect it to take around 3 months for the benefits to start showing. In my experience of prescribing the drug, it is not uncommon for spots to flare up initially before starting to settle. For this reason I typically prescribe a low dose for the first few weeks and gradually build it up over time."

What happens when you stop taking spironolactone for acne?

This can happen in both men and women. If this happens, your doctor may stop your treatment with this drug. This symptom usually goes away once you stop taking this drug. Low blood pressure and worsening kidney function: This drug may result in low blood pressure and worsening kidney function.

How much spironolactone can I take for acne?

When using Aldactone as an acne treatment, the most common dosage is between 50 to 100 mg daily1??. Many dermatologists start off prescribing 25 mg and work up to the target dosage over the course of several weeks. Your doctor will determine the most appropriate dosage for you, depending on your personal situation.

What do dermatologists prescribe for acne?

Usually the first choice for treating acne is tetracycline — such as minocycline or doxycycline — or a macrolide. Oral antibiotics should be used for the shortest time possible to prevent antibiotic resistance. Oral antibiotics are best used with topical retinoids and benzoyl peroxide.

Does spironolactone work for hormonal acne?

Originally formulated to treat hypertension and a few other cardiovascular troubles, spironolactone is a drug that, at a lower dose, can help with hormonal acne. It's also an androgen blocker (that delivers just the teensiest bit of progestin) and a diuretic. And though it treats hormonal acne, it's not a quick fix.

How long do you stay on spironolactone for acne?

The pill: 2 to 3 months. Spironolactone: A decrease in breakouts and oilness in a few weeks.

How do you treat hormonal chin acne?

What else can I do to clear hormonal acne?
  1. Wash your face in the morning and again in the evening.
  2. Apply no more than a pea-size amount of any acne product. Applying too much can dry out your skin and increase irritation.
  3. Wear sunscreen every day.
  4. Use only noncomedogenic products to reduce your risk of clogged pores.

Does hormonal acne ever go away?

Most often, acne will go away on its own at the end of puberty, but some people still struggle with acne in adulthood. Almost all acne can be successfully treated, however. It's a matter of finding the right treatment for you.

Does spironolactone make your breasts bigger?

Breast changes Breast enlargement may occur in 26% of women at high doses and is described as mild. Some women regard spironolactone-induced breast enlargement as a positive effect. Spironolactone also commonly and dose-dependently produces gynecomastia (breast development) as a side effect in men.

How can I stop hormonal acne?

What else can I do to clear hormonal acne?
  1. Wash your face in the morning and again in the evening.
  2. Apply no more than a pea-size amount of any acne product. Applying too much can dry out your skin and increase irritation.
  3. Wear sunscreen every day.
  4. Use only noncomedogenic products to reduce your risk of clogged pores.

Does spironolactone help with oily skin?

Basically, Spironolactone blocks androgen receptors and reduces the production of oil in the sebaceous glands, according to him. “With hormonal acne, androgen hormones (like testosterone) are elevated and can cause skin problems like oily skin, clogged pores, and acne around the neck and jawline,” he says.

What does spironolactone do to your hormones?

Spironolactone, the generic name for Aldactone®, works by lowering androgen levels in the body. Androgens are hormones that both males and females have, but males have higher levels of them. Spironolactone works by lowering the level of androgens, which lessens hair growth and improves acne.

Which pill is best for acne?

The best birth control pill for acne is a combination pill—one that contains both estrogen and progestin. The FDA has approved four such birth control pills for the treatment of acne: Ortho Tri-Cyclen, Estrostep Fe, Beyaz, and Yaz.

How do I know if my acne is hormonal?

How do you know if you have hormonal acne?
  • You're no longer in your teen years.
  • Your pimples pop up around your chin and jawline.
  • Your breakouts occur once a month.
  • You're seriously stressed.
  • You're dealing with painful cysts (versus blackheads and whiteheads).

What should you not take with spironolactone?

Avoid taking salt substitutes that contain potassium or potassium supplements while taking spironolactone. Try to avoid foods high in potassium (such as avocados, bananas, coconut water, spinach, and sweet potato) because eating these foods may lead to potentially fatal hyperkalemia (high blood potassium levels).

Can spironolactone cause weight loss?

Spironolactone will cause the elimination of water from the body, causing weight loss, but it does not cause fat loss directly. Although spironolactone may relieve symptoms caused by fluid retention and could be helpful for specific health conditions, there is no evidence that it promotes healthy long-term weight loss.

What happens if you take too much spironolactone?

Overdosing on spironolactone can result in: Drowsiness, dizziness, or confusion. Rash. Nausea, vomiting, or diarrhea.

Why am I still breaking out on spironolactone?

The reason spironolactone is still fairly unheard of by acne sufferers is likely due to its main use: treating high blood pressure and heart failure. While I'd taken the birth control pill since I was a teenager in an effort to combat period-induced breakouts, spironolactone works a bit more aggressively.

Can I drink alcohol while taking spironolactone?

Spironolactone and Alcohol While taking Spironolactone, consumption of alcohol, narcotics, or barbiturates (a sedative) can cause dizziness, lightheadedness, or fainting when you get up too quickly from a sitting or lying position. Therefore, it may be best to avoid drinking alcohol when taking spironolactone.

How many mg of spironolactone should I take for acne?

DOSAGES. The dosage of spironolactone for acne is 25-200 mg/day in one to two divided doses. A study that used 50 mg spironolactone twice a day on Days 5 through 21 of women's menstrual cycle had a high rate of success with low incidence of side effects (Harper, 2006).

Why am I getting cystic acne all of a sudden?

According to Rouleau, there are two possibilities for this type of breakout: hormones and dairy. "Cystic acne which usually occurs in the chin and jaw areas is the most common place to get acne — especially in adults," she says. "The reason for this is often due to the hormonal shifts and imbalances in the body.

Why am I breaking out on my chin?

Pimples happen when your pores are clogged with oil and dead skin cells. Research suggests that acne on your chin and jawline is often related to hormones , particularly in women. Hormones called androgens stimulate the production of sebum, which is the oil responsible for clogging pores.

Why isn't my skin clearing up?

If you don't see improvement after 4 to 6 weeks, add a second acne product to your treatment plan. This approach can help attack the different causes of acne. Bacteria, clogged pores, oil, and inflammation can all cause acne. Of course, the second treatment should attack a different cause of acne.

Why am I breaking out on one side of my face?

Acne on your cheeks? Check your phone and pillowcases. And anytime you hold your phone to your face, you're spreading that bacteria to your skin, potentially causing more acne. Persistent acne on one side of your faces tends to be due to dirty phones, pillowcases, and other habits like touching your face.